Dermavite®

What is Dermavite?

Dermavite is a non-prescription dietary supplement developed in conjunction with medical and skincare professionals for use with patients and clients that may have diets deficient in key vitamins, minerals and supplements necessary for the proper growth, repair, protection and overall health of skin, hair and nails. DERMAVITE is promoted to dermatologists and skincare professionals for recommendation to patients and clients that may require or benefit from specific nutritional/dietary support.

Dermavite® Hair, Nails, Skin Formula

Dermavite is a unique, coated, capsule-shaped, naturally colored tablet. The suggested use for adults and children 12 yrs. and older is two (2) tablets daily, taken with a meal and a large glass of water, or as directed by a healthcare professional.

Dermavite is presented for sale as a bottle of sixty (60) tablets. Package design/labeling has a “clean and contemporary” appearance.

The Non-GMO DERMAVITE formula is as follows:

Component                                                   Amount/Serving               % Daily Value (DV)

* Daily Value (DV) not established

Vitamins

Vitamin C (Ascorbic Acid) Antioxidant, Water Soluble Vitamin

A water-soluble vitamin necessary for the synthesis of collagen. It plays a cofactor role in the hydroxylation of lipine and proline and specifically induces collagen synthesis on the molecular level. Vitamin C also is important for infection resistance and capillary formation in the skin. When deficient in the diet, acne lesions increase in size and can become hemorrhagic.

Vitamin E (Tocopherol) Antioxidant, Fat Soluble Vitamin

A fat-soluble vitamin and active free radical scavenger, it plays a role in stabilizing cell membranes by inhibiting oxidation of poly-unsaturated fatty acids. Vitamin E deficiency can result in impaired vitamin A absorption. Combined with selenium, it has been shown to be helpful in acne patients with low RBC glutathione peroxidase levels. It has also been found to be helpful in scleroderma, beneficial in seborrheic dermatitis and protective for melanoma.

Vitamin B6 (Pyridoxine) B-complex, Water Soluble Vitamin

Pyridoxine plays a vital role in the multiplication and rapid replication of cells. It is involved in the metabolism of tryptophan and essential fatty acids; may be helpful for patients with acne vulgaris and acne rosacea. Pyridoxine has also been shown to be beneficial in premenstrual acne flares. A deficiency can result in seborrheic lesions.

Biotin (Vitamin B7) B-complex, Water Soluble Vitamin

Biotin is a water-soluble vitamin that’s a part of the vitamin B family. It’s also known as vitamin B7 and vitamin H. Your body needs biotin to help convert certain nutrients into energy. It plays an important role in the health of your hair, skin, and nails. Biotin has been shown to be deficient in patients with seborrheic dermatitis. Supplementation has been reported to improve severe seborrheic dermatitis (may improve the metabolism of scalp oils) and some forms of alopecia. Biotin deficiency is difficult to detect because of the lack of assay techniques (testing) to determine biotin concentrations in the blood.

Vitamin B5 (Pantothenic Acid) B-complex, Water Soluble Vitamin

Pantothenic acid, or vitamin B5, is an essential part of a healthy diet. A deficiency of this vitamin can harm your hair follicles, which may weaken them and lead to hair loss. Pantothenic acid is often taken in conjunction with the other members of the B vitamin family and maintaining adequate levels of these can improve the health of your hair and help prevent it from thinning.

Pantothenic acid and the other B complex vitamins are essential for maintaining the health of your hair and skin. Inadequate amounts in the diet can lead to multiple side effects, including hair loss.

Maintaining proper levels of pantothenic acid can strengthen your hair follicles and their cells. This vitamin contributes to the nourishment of hair follicles, helping them to function properly and promote the growth of your hair. Pantothenic acid can also help relieve the skin itching and flaking associated with dandruff and other similar disorders. Ridding your scalp of dead skin will keep your follicles clear of debris and encourage new growth.

Minerals

Calcium Key Mineral

Calcium is one of the body’s most sought-after minerals, so when your system lacks enough calcium, you can see it clearly in the health of your hair and nails. We all know the importance of ample calcium intake for healthy teeth and bones, but it’s also an essential mineral that benefits skin health. The human body contains more calcium than any other mineral; making up about 90% of our bone structure. It plays a major role in providing firmness and elasticity for the skin as well as all tissues and cells of the body. Dietary calcium can also help deter acne. A calcium deficiency will result in fragile and thin skin, loss of hair, weak bones and brittle nails. Pregnant and lactating women require more as the mother's calcium reserves are drawn on at these times. If you want to improve your overall skin health, then calcium is a must.

Zinc Key Mineral w/Antioxidant Activity

Zinc is an essential trace element with significant antioxidant activity; inhibiting free radical oxidation damage. It may also be involved in collagen synthesis. Up to 20% of body stores are found in the skin, 3-6 more times concentrated in the epidermis than the dermis. Clinical manifestations of deficiency include skin changes, dermatitis and alopecia. Zinc deficiency has been established in psoriasis patients and low zinc serum concentrations can slow healing and aggravate existing skin disorders. Zinc has been shown to speed wound healing following surgery and to be beneficial in acne patients.

Selenium Key Mineral w/Antioxidant Activity

Selenium, found in both the dermis and epidermis, is an antioxidant and effective oxygen trap. It is an essential component of the enzyme glutathione peroxidase, an inhibitor of the 5-lipoxygenase, the pathway which promotes formation of inflammatory leukotrienes. Loss of selenium from epidermal desquamation may increase in conditions of rapid cell turnover. It has shown to be helpful, along with vitamin E, in acne patients with low RBC glutathione peroxidase levels. Selenium has also been found to be deficient in patients with psoriasis and eczema. Because selenium stimulates apoptosis, it has been stated that it may reduce the risk of cancer.

Copper Key Mineral w/Antioxidant Activity

Copper is a component of tyrosinase, a vital metalloenzyme that functions in melanin production. It is also a cofactor of other enzymes involved in wound healing. Copper is important for collagen formation, elastin production and hair maturation.

Manganese Key Mineral

Present in melanocytes in high concentration, it may be involved in the auto-oxidation of melanin granules. Manganese is also necessary for arginase activity in the epidermis, which is often increased in disease with epidermal hyperplasia. Deficiency of this key mineral can cause dermatitis and several hair changes (e.g. color, growth, etc.).

Other Ingredients

OptiMSM (methylsulfonylmethane)

MSM (methylsulfonylmethane) is an organic, biologically active sulfur derived from the earth’s water cycle. While sulfur is present in many whole foods and unprocessed foods, it can be lost in the heating process necessary to cook foods. Sulfur is a necessary component of collagen and keratin for skin and nails.

Keratin is a protein that acts as the main structural component in your hair, skin and nails. It contains high levels of the sulfur-containing amino acid cysteine. That’s why burnt hair gives off a characteristic sulfurous smell. MSM may be beneficial for skin health by acting as a sulfur donor to keratin. This, in turn, can help strengthen this important protein.

MSM benefits include helping to support strength and flexibility in nails and hair. Plus, for skin health, MSM works in the body to help with collagen formation and works with vitamin C in tissue and skin health. It also helps reduce inflammation, which can damage skin cells and cause signs of premature aging like wrinkles.

There is also research on its effectiveness with hair growth and retention, showing MSM sulfur can form bonds essential to strengthening hair and influencing hair growth.

Silica Key Mineral

Silica is a trace mineral that helps strengthen your body’s connective tissues — muscles, tendons, hair, ligaments, nails, cartilage and bone — and is a vital component of maintaining healthy skin. Silica deficiency could lead to skin losing its elasticity, which results in premature aging and a slower healing of skin wounds. To increase the speed of wound healing, along with boosting skin health, hair health and bone health you should combine silica with zinc for maximum health benefits.

Hydrolyzed Collagen

Hydrolyzed collagen contains a mixture of different types and combinations of collagen peptides. Because of its smaller size, hydrolyzed collagen is easier to digest and use. The absorption rate of hydrolyzed collagen is said to be over 90% compared to only 27% or less in food. In addition to improving structural integrity and elasticity of the skin, collagen can also improve the skin’s ability to retain moisture and may fight UVB photodamage, which in turn promotes healthier and younger looking skin.

There is also mounting clinical evidence of collagen’s benefits in strengthening the collagenous structures of hair and nails. A study in the Journal of Investigative Dermatology reveals that collagen is strongly deposited in hair follicles, and the lack of collagen delays hair cycling and growth. In a six-month study looking at brittle nails, researchers found that daily supplementation with collagen resulted in increased nail growth and improved brittle nails in conjunction with a notable decrease in the frequency of broken nails. Taking collagen may increase the strength of your nails by preventing brittleness. Additionally, it may stimulate your hair and nails to grow longer.

L-Methionine

L-Methionine is an amino acid that works together with B complex vitamins, and other nutrients to help your body manufacture new protein tissues. Methionine helps your body to create new protein that makes your nails stronger and more resistant to breaking. L-Methionine cannot be produced directly by the body, so in order to get the proper bodily intake, we depend on dietary sources and supplements.

The key element of L-Methionine is sulfur. To manufacture keratin in the hair shaft, sulfur is critical. When methionine is included in the diet, your body can manufacture keratin. Keratin is the main material of the hair shaft, one of the proteins that are essential for your appearance. Methionine also helps to smooth your hair and give it more shine. It is the natural way to bring out the shine in your hair.

Methionine also helps improve the skin tone by boosting collagen production.

Collagen, like keratin, is a type of protein. And this becomes more important the older you get as your skin can not produce new skin cells. Supplementing with L-Methionine makes this whole process much easier. Taking supplements with methionine will help to keep your nails strong and skin and hair looking fresh and smooth.

Citrus Bioflavonoids

Citrus bioflavonoids maintain healthy bones, nails, skin, hair and strong blood vessels. They also act as an antioxidant and protect the body from free radical damage. Bioflavonoids are found in citrus fruits and help maintain capillary strength and intensify the effect of vitamin C in the body. They cannot be produced by the body and must be taken through food or supplements.

Hydrolyzed Keratin

When keratin is hydrolyzed (broken down into smaller components) and used in supplements, it helps create a protective barrier on the hair while simultaneously imparting shine. Hydrolyzed keratin has also been shown to replenish the hair and skin with moisture while also improving the skin’s elasticity. As a result of its moisturizing properties, supplements containing hydrolyzed keratin are a favorable option for those with limp, dry and brittle hair.

Hyaluronic Acid

Hyaluronic acid is a supplement that contributes to the maintenance of healthy skin and nails. Naturally occurring in the human body, hyaluronic acid may help hydrate and repair skin, help strengthen nails and add shine to hair.

Hyaluronic acid a critical component of collagen, a protein necessary for healthy skin, hair and nails and proper collagen levels may contribute to the maintenance of youthful-appearing skin. The health and beauty of your hair, skin, and nails is dependent on your body's ability to produce healthy amounts of collagen. As we age, the amount of collagen produced and held in the body may begin to decline, which may have negative effects on the health and appearance of your hair, skin, and nails.

Alpha-Lipoic Acid

Alpha-Lipoic Acid is an antioxidant that can increase the effectiveness of other nutrients, specifically other antioxidants such as vitamin C and vitamin E.

Early research suggests alpha-lipoic acid use might help reduce fine lines and skin roughness caused by sun damage. Also, taking a specific product containing alpha-lipoic acid and other ingredients, such as those in Dermavite®, can help improve skin elasticity and reduce the wrinkles and roughness of aging skin.

Proprietary Blend

The proprietary blend in Dermavite includes several ingredients that are known to help nourish, repair or maintain healthy skin, hair or nails.

SUGGESTED USE

Adults take 2 tablets daily or as directed by your health care professional. This product is best taken with food and a large glass of water.

SIDE EFFECTS

No adverse effects have been reported.

STORAGE

Store in a cool, dry place, away from direct light. Keep out of reach of children.

REFERENCES:

Sano T, et al. Arch Dermatol Res. 2005 Feb;296(8):359-65. [Keratin].

Matsuo M, et al. Gerontology. 2004 Jul-Aug;50(4):193-9.Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000

Moses Z,. Scheinfeld N, Clinical Advisor, 2010 October 01. Dystrophies of the Nail

Iorizzo M, et al. J Cosmet Dermatol. 2004 Jul;3(3):138-44.

Hochman LG, Scher RK, Meyerson MS. Cutis 1993;51:303–5. [Biotin].

Antony AC. Megaloblastic Anemias. In: Hoffman R, Benz Jr EJ, Shattil SJ, et al. Hematology: Basic Principles and Practice. 3rd ed. New York, NY: Churchill Livingstone 2000: 451-79.

Omeroğlu S, Peker T, Türközkan N, Omeroğlu H. ArchOrthop Trauma Surg. 2009 Feb;129(2):281-6. doi: 10.1007/s00402-008-0603-0. [Vitamin C].

Ives SJ, et al. Hypertension. 2014 Mar;63(3):459-67. doi: 10.1161/HYPERTENSIONAHA.113.02255.

Mocchegiani E, et al. Mech Ageing Dev. 2014 Mar-Apr;136-137:29-49.doi: 10.1016/j.mad.2013.12.007. Epub 2014 Jan 2. Review.

Yousefi M, et al. Indian J Dermatol. 2014 Nov;59(6):630. doi:10.4103/0019-5154.143567.